Archive for the ‘brain fitness’ Category

Daydreams may solve complex problems

Tuesday, June 30th, 2009

This article published on the website Globe and Mail gives an interesting insight into daydreaming and how it may be useful to us.

http://www.theglobeandmail.com/life/health/daydreams-may-solve-complex-problems/article1134033/

Letting your mind wander is not a waste of time, according to a new study 

Comments By Marina Jiménez Last updated on Thursday, May. 14, 2009 03:12AM EDT

People spend one third of their waking lives daydreaming. But letting your mind wander is not a waste of time, according to a new study. It’s a chance for the brain to stop focusing on immediate tasks, and subconsciously resolve important life problems.

The study, published yesterday in the Proceedings of the National Academy of Sciences, shows that brain areas associated with complex problem solving, previously thought to go dormant during daydreaming, are in fact highly active.

“A lot of people reject daydreaming as a wasteful activity,” says Kalina Christoff, the study’s lead author and a University of British Columbia psychology professor. “But our study suggests that if you daydream, you might be able to advance some of your current concerns.”

The study put 15 research subjects through a functional MRI for 90 minutes, to examine the metabolic processes of their brains. They completed a simple, routine task of pushing a button when numbers appeared on a screen.

Prof. Christoff tracked the research subjects’ attentiveness through brain scans, subjective reports and by monitoring their performance of the task. She found that two key regions of the brain were active during daydreaming: the “default network,” associated with easy, routine mental activity, and the brain’s “executive network,” associated with high-level, complex problem-solving.

Usually when one network is working, the other isn’t. It is rare to see them working in tandem, the paper concludes. As well, the brain activity was most active when the research subjects weren’t aware they were daydreaming.

“When your mind wanders, a different kind of thinking occurs,” said Prof. Christoff. “When you aren’t trying to solve problems deliberately, it provides more mental space, you make connections and let your mind go wherever it wants.”

She has long been interested in spontaneous thought – but it is difficult to study because it doesn’t occur on cue. But now studies are being designed that permit scientists to look at the quantity and quality of brain activity during “mind wandering.”

Prof. Christoff says that many of her best research ideas have come to her when she is in the car, daydreaming.

“Driving is the perfect activity for letting your mind wander because it is highly automatized and requires only a small part of our attention,” she said. “When you daydream, you may not achieve your immediate goal, say reading a book or paying attention in class. But your mind may be taking that time to address more important questions in your life.”

She compares it to mulling over a life decision and letting it circulate in your brain, as opposed to deliberately weighing the pros and cons. Prof. Christoff runs UBC’s Cognitive Neuroscience of Thought Laboratory, which studies neural and cognitive mechanisms of human thought, reasoning and problem solving. Her research team for the study included members who are now at Stanford University and the University of California at Santa Barbara.

Encouragement improves your game better than criticism, claim scientists

Saturday, May 2nd, 2009

rom The Telegraph website:

The ‘hairdryer’ treatment and criticism may get quick results, but sportsmen respond much better to kinds words of encouragement and support, scientists have found.

By Richard Alleyne, Science Correspondent

Last Updated: 2:35PM BST 01 May 2009

Sportsmen and women could get the edge on their opponents by accepting more emotional support in their personal and professional lives. A study by the University of Exeter, showed the extent to which a sympathetic ear or regular words of encouragement can improve sports performance.

Previous studies have linked ’social support’ to performance in golf and other sports and psychologists are regularly employed to improve performance. But doubts have still remained over its effectiveness – with many still believing that criticism is the best path to results. Now for the first time, researchers claim they have proved it works – at least for golfers – after showing proper emotional support can improve their handicap by nearly two in less than a month.

Dr Paul Freeman said that a player’s game is definitely affected by their frame of mind and negative feedback could have the opposite effect.

“There are times when the hairdryer treatment works but as a general rule positive support is going to have more long term benefits,” he said.

“Over a longer period I definitely think this support is more affective.”

The study, published in the Journal of Applied Sport Psychology, focused on three male golfers, two amateurs and one professional, who all competed at regional, national and international level. For half of the study the golfers were each given regular one-on-one support by Dr Freeman of the University of Exeter.

 Dr Freeman offered a range of support including listening to the golfers as they talked through their problems, offering encouragement and reassurance before competitions, and helping with practical issues, such as organising accommodation during competitions.

To provide comparative data, the researchers looked up the performance of the three golfers prior to the study.

Over 10 games, all three golfers performed better when they were receiving support from Dr Freeman. The players improved by an average of 1.78 shots per round, which could be significant at high-level golf. Dr Freeman said:

“It is significant that the support I offered, as a relative stranger, had such a marked influence on their results.

“The findings suggest that amateur and professional athletes would benefit from seeking social support, whether this is from a friend or family member or even from a professional.”

Experiences make us happier than things

Monday, March 30th, 2009

Here’s a new twist on the ‘money doesn’t make you happy’ senario from Startribune.com. It would certainly stand to reason that experiences have the possibility to make us happier, simply because memories last longer than material things generally – but do they need to be ‘good’ experiences? I suppose they do …

Experiences make us happier than things By SHARI ROAN, Los Angeles Times Last update: March 29, 2009 – 12:59 PM

Money is an emotional issue, especially during economic hard times. Social scientists have always warned that once a person’s basic needs are met, money doesn’t buy happiness. But if you’re wondering, or maybe even arguing over, what to do with any precious discretionary income these days, a new study suggests how to get the biggest emotional bang for your buck.

Ryan Howell, an assistant professor of psychology at San Francisco State University, found that buying experiences — such as vacations, going to the theater or renting a sailboat — gave people more happiness than buying material things.

The study, of 154 people ages 19 to 50, showed that experiences increase happiness because they are often social in nature. In addition, however, experiences tend to make people feel more alive.

“People report a sense of feeling invigorated or inspired,” Howell said.

Experiences might also yield more happiness because people are left with positive memories, a sort of return on their investment.

“It’s not that material things don’t bring any happiness. It’s just that they don’t bring as much,” Howell said. “You’re happy with a new television set. But you’re thrilled with a vacation.”

The study might yield some lessons for Americans in despair over the recession. “For whatever you can afford, you’ll maximize your happiness, and the happiness of others around you, if you spend it on a life experience,” he said.

It doesn’t matter how much money you spend, either.

“Whether you spent a little or a lot on the life experience, you still have the same level of happiness,” he said.

The study was presented recently at an annual meeting of the Society for Personality and Social Psychology and will be published this year in the Journal of Positive Psychology.

Video Games Can Encourage Positive Behavior, Too

Saturday, March 28th, 2009

With so much bad press for video games and the people who partake in them, this article  from Miller-McCune makes a refreshing change

 By: Tom Jacobs  |  March 27, 2009  |  01:07 PM (PDT)  |  

 

If violent video games encourage violent behavior, as a series of studies suggests, do prosocial games — those that reward helpful behavior — inspire players to act in more constructive, cooperative ways? A newly published paper, featuring studies of three different age groups in three different countries, suggests the answer is yes.

“Video games are not inherently good or bad,” concludes the team of 12 researchers led by psychologist Douglas Gentile of Iowa State University. Their findings suggest this popular form of entertainment “can have both positive and negative effects.”

The paper, published in the Personality and Social Psychology Bulletin, begins with a survey of secondary school students in Singapore (adolescents in the equivalent of seventh or eighth grade). They listed their favorite games, the number of hours they spend playing them each week and how often the games involve a) helping others, or b) hurting or killing others.

They were then asked a series of questions to measure their emotional awareness and empathy for others. After controlling for several variables, “prosocial game exposure was positively related to prosocial behavior,” the researchers report.

The second survey was of fifth-, eighth- and eleventh-grade students in Japan. They were asked how often in the past month they had played games in which characters help troubled people, or games in which friendship or a positive parent-child relationship was featured.

Finally, the youngsters were asked how often in the previous month they had acted in one of four specific helpful ways (such as “I helped a person who was in trouble”). The researchers discovered a strong relationship between playing prosocial games and self-reported prosocial behavior.

For the third study, the researchers conducted an experiment using 161 American college students, who were randomly assigned to play specific parts of one of six video games. Two of the games were violent (Ty2 and Crash Trinsanity), two were neutral (Pure Pinball and Super Monkey Ball Deluxe), and two were deemed prosocial: Chibi Robo, in which the goal is to make your family happy by cleaning up and helping out with the chores; and Super Mario Sunshine, in which players gain points by cleaning up a polluted island.

After playing one of the games for 20 minutes, participants were asked to assign a partner 11 puzzles to complete. They were told that if their partners completed 10 of the puzzles within 10 minutes, the partner would win a $10 gift certificate. They could choose puzzles from one of three difficulty levels, depending upon whether they were disposed to help their partner win the prize, or to place difficulties in his or her path.

The researchers found that “participants who played a prosocial game helped their partners significantly more than did either those who had played a violent game, or those who had played a neutral game.” Furthermore, “the violent gamers hurt their partners significantly more than did either those who had played a prosocial game or those who had played a neutral game.”

Taken together, the three studies found that “prosocial game play was significantly positively related to all four measured prosocial behaviors and traits” — helping behavior, cooperation and sharing, empathy and emotional awareness. These findings complement a 2008 study from Britain that found listening to songs with prosocial lyrics encourages charitable behavior.

According to Gentile and his colleagues, these results “make it clear how critical it is to separate amount of play from the content of play.” In other words, video game playing per se isn’t the issue: Rather, the important factor is the underlying messages contained in specific games.

“Content matters,” they conclude, “and games are excellent teachers.”

Visual learners convert words to pictures in the brain and vice versa

Friday, March 27th, 2009
This interesting article published in Science Centric on 26 March 2009 demonstrates why, as an NLP Learning Coach, I realise how important it is for us to learn in our prefered style. If a visual person only ever hears the voice of their teacher telling them the things they need to know, the visual person has to convert that teaching into visual images before they can fully understand it. This makes twice the work. Alternatively, the student may just loose interest in learning at all, because they haven’t learned the skill of converting the information yet. As an NLP Learning Coach, I help my clients know their prefered learning type, and then show how they can use that information to help them the most. See further details at www.anitamitchell.co.uk. Here’s the article.

A University of Pennsylvania psychology study, using functional magnetic resonance imaging technology to scan the brain, reveals that people who consider themselves visual learners, as opposed to verbal learners, have a tendency to convert linguistically presented information into a visual mental representation. The more strongly an individual identified with the visual cognitive style, the more that individual activated the visual cortex when reading words.

The opposite also appears to be true from the study’s results.

Those participants who considered themselves verbal learners were found under fMRI to have brain activity in a region associated with phonological cognition when faced with a picture, suggesting they have a tendency to convert pictorial information into linguistic representations.

The study was presented this week at the 16th Annual Cognitive Neuroscience Society Meeting.

Future research based on the findings from this study may be able to determine whether cognitive styles are something one is predisposed to or can learn. Depending on the flexibility with which one can adopt a style, educators could cater to one style over another to improve learning.

It has long been thought that propensities for visual or verbal learning styles influence how children acquire knowledge successfully and how adults reason in every-day life; however, there was no empirical link to this hypothesis from cognitive neuroscience.

‘Often, job applicants are required to offer opinion on whether they consider themselves visual or verbal learners,’ Sharon Thompson-Schill, professor in the Department of Psychology and a member of Penn’s Centre for Cognitive Neuroscience, said. ‘Some school districts even require students to wear buttons identifying themselves as visual or verbal learners. Until this study, however, there was no direct evidence linking these cognitive styles to specific neural systems in the brain.’

In the Penn study, visual and verbal cognitive styles were measured in 18 subjects by a self-report exam called the Verbaliser – Visualiser Questionnaire. The Wechsler Adult Intelligence Scale, a standard intelligence test used here to grade visual against verbal learning styles, then measured cognitive abilities. Participants subsequently participated in a functional magnetic resonance imaging experiment.

During the fMRI session, participants performed a novel psychological task, a more sophisticated version of the childhood board game Memory, involving both word-based and picture-based feature-matching conditions designed to permit the use of either a visual or a verbal processing style.

Results of the study demonstrated a pattern of activity in modality-specific areas of the brain that distinguished visual from verbal cognitive styles. The areas did correspond with prior knowledge of brain utilisation. During word-based tasks, activity in a functionally defined brain region that responded to viewing pictorial stimuli, the fusiform gyrus, correlated with self-reported visualiser ratings on the VVQ test.

In contrast, activity in a phonologically related brain region, the supramarginal gyrus, correlated with the verbaliser dimension of the VVQ during the picture-based condition. These findings suggest that modality-specific cortical activity underlies processing in visual and verbal cognitive styles.
Source: Penn: Office of University Communications

Kids with ADHD May Learn Better by Fidgeting

Thursday, March 26th, 2009

This article published on March 25th 2009, in Time, Health & Science talks about a four year study which suggests that a better approach (than some of the medications currently prescibed)  for ADHD children (at least those who are not hyperactive to the point of breaking things) is to let them move around as much as they would like.

Cognitive Hypntherapy and NLP have long suggested that we need to work at our clients pace and allow them to do it their way, not our way. We, as therapists know that all behaviour has a purpose. It’s good to find our that studies back up our therories.

Here is the article. Hope you find it interesting.

www.anitamitchell.co.uk

 

By John Cloud

Like nose-picking and a preoccupation with feculence, the inability to sit still for long periods is a defining characteristic of childhood. But children with attention-deficit/hyperactivity disorder (ADHD) often squirm constantly, even when other kids can remain still. Many parents and teachers respond by trying to get ADHD kids, at any cost, to stop fidgeting. The assumption is that if they could just stop wriggling, they would be able to focus and learn.

But a new study suggests that a better approach for ADHD kids (at least those who are not hyperactive to the point of breaking things) is to let them move all they want. That’s because many kids use their movements — like swiveling in a chair or folding a leg underneath themselves and bouncing in a desk seat or repeatedly lolling and righting their head — the way many adults use caffeine: to stay focused. In other words, it may be that excessive movement doesn’t prevent learning but actually facilitates it. (See the top 10 medical breakthroughs of 2008.)

Longtime ADHD researcher Mark Rapport supervised the study, which is set to be published in the Journal of Abnormal Child Psychology. Rapport, a professor at the University of Central Florida (UCF) in Orlando, notes that our activity level — how much we move around in everyday situations — is one of the most fixed parts of our personalities. If you are a fidgety kid, you will be a fidgety adult, even if you learn to manage your movements with caffeine, stress-reduction, a personal trainer or other adult accoutrements.

The idea that stimulants like caffeine (or Ritalin or even something stronger like cocaine) can help you sit still and pay attention seems counterintuitive at first. But that surprising fact lies at the heart of Rapport’s work: stimulants augment your working, or short-term, memory, where information is stored temporarily and used to carry out deliberate tasks like, say, solving a challenging math problem. ADHD kids have a hard time with working memory because they lack adequate cortical arousal, and Rapport believes that their squirms and fidgets help stimulate that arousal.

His study was small — just 23 boys ages 8 to 12 participated — but uncompromisingly meticulous; it took four years to complete. Twelve of the boys had an ADHD diagnosis. The other 11 were developing normally. All underwent a battery of tests at Rapport’s lab over four consecutive Saturdays.

Since I’ve always been fidgety, I asked Rapport if he wouldn’t mind putting me through the same tests he gave the boys. And so last week I found myself at the UCF Psychology Department, where a grad student affixed a device called an actigraph to my left wrist. Actigraphs look like digital watches and generate a signal each time they are moved, even slightly. They allow researchers to measure, quite precisely, a subject’s kinetic activity. The boys in Rapport’s experiments wore actigraphs on their ankles as well as their wrists because kids are often just as twitchy below the waist as above. (See the most common hospital mishaps.)

Wearing the actigraph, I sat before a computer in a small windowless room and took working-memory tests. For one test, I had to recite aloud a series of numbers that appeared on the screen. I was asked not only to remember the numbers but also to restate them in proper numerical order. So if I saw 4, then 3, then 1, then 8, I had to say, “One, three, four, eight.” Each series of numbers also included a random letter, which I had to state at the end: “One, three, four, eight, D.”

At first the test sounded simple, not least because I knew an 8-year-old could ostensibly complete it. But I found it quite difficult. Working-memory tests require intense concentration, and I was distracted because I was nervous. Rapport, several of his grad students, a UCF public relations official and a friend of mine were all watching me through an open doorway while I performed the tests. I ended up scoring worse than some of Rapport’s kids.

My experience of being nervous was instructive because it mimicked, in a way, the cognitive strain under which an ADHD kid takes such tests. ADHD compromises the brain’s executive functioning — its ability to master unexpected exercises. The same way I got nervous, ADHD kids get momentarily lost, their attention fractured for a few seconds. Think about when you’re reading and get to the end of a paragraph and realize you haven’t been paying attention: that’s what it’s like for ADHD kids, all the time. My actigraph scores confirmed that I wasn’t operating normally for a 38-year-old adult. Instead, during the experiment, I displayed the involuntary body movements of a typical 12-year-old boy. (See pictures of a diverse group of American teens.)

Rapport also conducted a control experiment with the boys in which they watched the pod-racing scene from Star Wars: Episode I — The Phantom Menace. He showed me a video of a couple of the boys watching the scene, and I was shocked: even the ADHD kids who had spun around endlessly during their cognitive tests sat perfectly still while they watched the pod race. The film clip required almost no working memory, no concentrated effort. The scene simply washed over the passively watching boys, none of whom had to move around to stay alert.

Which suggests a classroom technique for ADHD kids: Don’t overly tax their working memory. Rapport, who used to be a school psychologist, says the average teacher doesn’t understand how ADHD kids process information. “If you go into a typical classroom,” he told me, “you might hear, ‘Take out the book. Turn to page 23. Do items 1 through 8, but don’t do 5.’ And you’ve just given them four or five directions. The child with working-memory problems has dropped three of them, and so he’s like, ‘Page 23 — what I am supposed to do?’ ” Similarly, a parent might tell a kid, “Take my keys, go to the car, get your sister’s toy, and before you go, take the trash with you.” The ADHD kid will get to the car without remembering what else to do. Their instructions must be broken down carefully because their working memory is weak.

When I asked Rapport whether there’s a cure other than breaking down instructions, his answer was a bit depressing: no. ADHD is incurable. Drugs like Ritalin are a common answer for controlling the condition, which affects about 3% to 5% of children, but Rapport notes that they have proven to be only a limited solution. In the short term, they can facilitate a child’s ability to read — undoubtedly a crucial benefit — but Rapport says longitudinal studies have failed to show that Ritalin or other psychostimulants have consistent long-term behavioral effects. (Even if they did, another question would arise: Would you want to be dependent on a stimulant for the rest of your life?) Rapport hopes that his work will lead to the development of early behavioral and cognitive interventions that could help the youngest ADHD kids recognize, predict and somehow avoid ADHD’s concentration gaps.

Such research is in its infancy, though, and if you have a child with ADHD, it’s important to understand that he processes the world in a different way. He might be (literally) running circles around you, but that may be his way of paying attention.

Think ahead, live longer

Wednesday, March 18th, 2009

This article published in ABC Health and Wellbeing is very much in keeping with thoughts from Cognitive Hypnotherapy – imagine the future you want, and then allow the unconscious mind to guide you towards it (whilst doing a little work along the way to help the process, of course! See my website for details www.anitamitchell.co.uk):

The Pulse

by Peter Lavelle

People who plan ahead and think of the future are often healthier than those living for the here-and-now, argues a prominent US psychologist. Published 12/03/2009 

Do you live for the present, without worrying about tomorrow? Do you view the future through the prism of what’s happened to you in the past? Or do you keep one eye on the future in everything you do? Whichever you do, will impact directly on your health, argues US psychologist Philip Zimbardo. Zimbardo, Emeritus Professor at Stanford University, is the author of a new book The Time Paradox: The New Psychology of Time That Will Change Your Life. In it he argues people tend to make decisions based on whether they are orientated to the past, present or future. Some people are dominated by their past experiences and this influences how they make decisions now. These past experiences may be positive – family or cultural traditions or rewards for good things they’ve done in the past – or they may be negative events – past traumas influencing what they do in the present. People with post-traumatic stress syndrome have been negatively influenced by their past. Other people are orientated towards the present. They seek immediate rewards, without much thought for the future, and are influenced by their body sensations and physiology (hunger, thirst, desire for sex etc) or what their peer group is doing. Rather than plan ahead, these people often rely on luck or fate and they tend to have lower levels of impulse control and emotional stability. Zimbardo says people who have addictions are very often present-thinkers, as are gamblers or those who run up credit card debts. Then there are people who are focused on the future, these people think of the consequences of their actions. They are good at controlling their egos and impulses; are conscientious, consistent, non-aggressive, and have low levels of depression. In reality we all have a bit of past, present and future orientation, but we tend to be skewed to one and underuse the others, says Zimbardo. He argues your time perspective may depend on many things including the climate you live in, your religion, your education (more educated people tend to be more future thinking), your gender (women are more future thinking than men), what income you earn (poorer people tend to be more present-orientated) and your age. In fact, we are all born present-thinkers, but become more focused on the future as we age, often in response to pressure from society. Many of the stories, nursery rhymes and games we play as kids encourage us to be forward-thinking; as does school and higher education. But being totally future-oriented is also unhealthy, says Zimbardo. Excessive emphasis on the future causes anxiety in the here and now, (as to how things might turn out) which can lead to social isolation and performance anxiety (especially anxiety about sexual performance). This is where present-oriented thinkers have some advantages; they make friends easily (being the ‘life of the party’), they are creative thinkers and have plenty of energy to enable them to achieve their goals. Being past-oriented (especially if your past experiences are positive) also has some advantages. Your family or culture may give you a sense of identity and continuity and provide you with positive role models. So what we need is a balance of all three ways of thinking. Healthy future So what does all this have do with your health? Zimbardo suggests there’s a very strong correlation between future orientation and health – the more future-oriented you are, the healthier you’ll be and the longer you’re likely to live. Research published in the British Journal of Health Psychology last month supports Zimbardo’s theory. Studies show people who are future thinkers tend to use drugs less, and adopt safe sex practices, the researchers say. Future thinkers also tend to be less likely to smoke and have healthier body mass indices, they conclude, after studying a group of about 400 people who answered questions about their health and lifestyles and who also underwent psychological testing including the Zimbardo Time Perspective Inventory (ZPTI) – a questionnaire Zimbardo helped develop in 1999 to test how people’s time perspective affects their decision making. (If you’re curious about which orientation you might be, do Zimbardo’s inventory yourself – just follow the link at the bottom of this page). On the other hand, other studies have shown that future-thinking doesn’t have much effect on whether people will get vaccinated, or stick to taking blood pressure or cholesterol medications. So future-thinking seems to be a factor in changing some behaviour but not others, say the British researchers. Getting the message out One of the challenges facing policymakers and health workers in preventative health is how to get people to forego junk food, drugs and alcohol, a sedentary lifestyle, for rewards that may be long into the future. But some public health messages may not be reaching their intended audience, says Zimbardo. Anti-drug campaigns warning of the future health risks of drug taking, for example, may be doomed to failure because their target audience (people inclined to use drugs) often live in the present and won’t listen to messages about the future. Peter Sainsbury, an Adjunct Professor of Public Health at Sydney University, agrees one of the challenges of mounting an effective public health program is to get people to change their behaviour for long-term benefits. “So you may need to give them a reason to change their behaviour in the here-and-now,” says Sainsbury. “For example, smokers may be more likely to quit if they think there’s an immediate benefit – better smelling breath, more success with the opposite sex for example, rather than the promise of better health twenty years from now.”

Slow Starvation of Brain Triggers Alzheimer's

Saturday, January 10th, 2009

www.anitamitchell.co.uk

By LiveScience Staff

posted: 24 December 2008 01:06 pm ET

 

A slow starvation of the brain over time is one of the major triggers of the biochemistry that causes some forms of Alzheimer’s, according to a new study that is helping to crack the mystery of the disease’s origins.

An estimated 10 million baby boomers will develop Alzheimer’s in their lifetime, according to the Alzheimer’s Association. The disease usually begins after age 60, and risk rises with age. The direct and indirect cost of Alzheimer’s and other dementias is about $148 billion a year.

Robert Vassar of Northwestern University, the study’s lead author, found that when the brain doesn’t get enough of the simple sugar called glucose — as might occur when cardiovascular disease restricts blood flow in arteries to the brain — a process is launched that ultimately produces the sticky clumps of protein that appear to be a cause of Alzheimer’s.

Working with human and mice brains, Vassar discovered that a key brain protein is altered when the brain’s supply of energy drops. The altered protein, called eIF2alpha, increases the production of an enzyme that, in turn, flips a switch to produce the sticky protein clumps.

“This finding is significant because it suggests that improving blood flow to the brain might be an effective therapeutic approach to prevent or treat Alzheimer’s,” Vassar said.

The best ways to improve blood flow to the brain and thereby reduce the chances of getting Alzheimer’s is to reduce cholesterol intake, manage high blood pressure and exercise, especially entering mid-life.

“If people start early enough, maybe they can dodge the bullet,” Vassar said. For people who already have symptoms, vasodilators, which increase blood flow, may help the delivery of oxygen and glucose to the brain, he added. The study is published in the Dec. 26 issue of the journal Neuron.

No candy bars

When it comes to prevention of Alzheimer’s, eating candy bars is not the solution to improving the flow of blood glucose to the brain, Vassar told LiveScience.

A decreasing blood flow to the brain happens over time, as we age, and that slowly starves the brain of glucose. This could be a general aging phenomenon, or it could be that some individuals are particularly prone to it, Vassar said. Also, decreased blood flow is associated with atherosclerosis, or hardening of the arteries, and hypertension, or high blood pressure.

“We need to improve our cardiovascular health, not eat more sugar,” Vassar said. “What is coming out in terms of the epidemiological studies is that exercise during mid-life is one of the best prevention strategies for Alzheimer’s disease, so people should stay active physically, and they should watch their diets and reduce cholesterol intake, because cholesterol contributes to atherosclerosis, and that is true for the heart and the rest of the body as well as for the brain.”

Vassar said it also is possible that drugs could be designed to block the elF2alpha protein that begins the formation of the protein clumps, known as amyloid plaques.

Earlier Alzheimer’s findings

Ten years ago, Vassar discovered the enzyme, BACE1, that was responsible for making the sticky, fiber-like clumps of protein that form outside neurons and disrupt their ability to send messages.

But the cause of the high levels of the protein in people with the disease has been unknown. Vassar’s new study now shows that energy deprivation in the brain might be the trigger starting the process that forms plaques in Alzheimer’s.

Vassar said his work suggests that Alzheimer’s disease may result from a less severe type of energy deprivation than occurs in a stroke. Rather than dying, the brain cells react by increasing BACE1, which may be a protective response in the short term, but harmful in the long term.

“A stroke is a blockage that prevents blood flow and produces cell death in an acute, dramatic event,” Vassar said. “What we are talking about here is a slow, insidious process over many years where people have a low level of cardiovascular disease or atherosclerosis in the brain. It’s so mild, they don’t even notice it, but it has an effect over time because it’s producing a chronic reduction in the blood flow.”

Vassar said when people reach a certain age, some may get increased levels of the enzymes that cause a build-up of the plaques. “Then they start falling off the cliff,” he said.

London cabbies have bigger hippocampi

Monday, December 15th, 2008

London cabbies’ brains grow on the job. According to studies by scientists at the University College London Institute of Neurology — the first published in the April 11, 2000, issue of Proceedings of the National Academy of Sciences with follow-up research presented in 2006 and 2007 — these professional drivers have a larger posterior hippocampus, the brain region tied to learning and navigation.

Researchers credit complex daily tasks, such as navigating a labyrinth of 320 standard routes in a six-mile area, with increasing brain size. And functional MRI demonstrated that the longer on the job, the bigger the brain.

Still, there may be a price. As brain regions continually competed for space, the posterior hippocampus grew while the anterior hippocampus, which is associated with memory, decreased. “The brain has enormous plasticity,” says Edward Taub, PhD, a behavioral neuroscientist at the University of Alabama at Birmingham. He has studied neuroplasticity since the 1970s. “Every part of the brain is used. The more you use a function, it may be at the expense of another.”

As an outgrowth of the early taxi driver studies, U.S. scientists began exploring the effects of employing complicated navigational skills. At Brandeis University in Waltham, Mass., scientists created the virtual taxicab video game to study the way brains work. As subjects play, they become increasingly proficient in navigating complex routes, which researchers believe is tied to building cognitive maps of the environment.

Additionally, German scientists reported in the June 2006 issue of The Journal of Neuroscience that the brains of German medical students, while studying for final exams, showed increases in the posterior hippocampus, similar to the London cabbie study. Three months later, according to MRI imaging, the hippocampus had returned to its former size.

Steps to a nimble mind: Physical and mental exercise help keep the brain fit

Wednesday, November 12th, 2008

 

HEALTH & SCIENCE

Neuroscience is uncovering techniques to prevent cognitive decline.

By Kathleen Phalen Tomaselli, AMNews correspondent. Nov. 17, 2008.


The brain — containing 100 billion neurons, 900 billion glial cells, 100 trillion branches and 1,000 trillion receptors — reacts to stimuli in a series of electrical bursts, spanning a complex map of connections. Whether calculating an algorithmic equation or learning the tango, our brain continuously changes in response to our ideas, actions and activities.

Each time a dance step is learned, for instance, new pathways are formed. “Dancing is excellent for the brain and body,” says Vincent Fortanasce, MD, clinical professor of neurology at the University of Southern California in Los Angeles. He wrote the Anti-Alzheimer’s Prescription. “Not only are you moving around more, your brain is in constant motion as it recalls steps and movements.”

It’s an example that highlights a wave of new thinking about the importance of brain fitness.

Until recently, conventional wisdom held that our brains were intractable, hard-wired computers. What we were born with was all we got. Age wore down memory and the ability to understand, and few interventions could reverse this process. But increasingly, evidence suggests that physical and mental exercise can alter specific brain regions, making radical improvements in cognitive function. “When you challenge the brain with new skills and new ways of doing things, it increases connections in the brain,” says Ericka P. Simpson, MD, a neurologist who co-directs the MDA Neuromuscular Clinics and directs the ALS clinical research division at the Methodist Hospital System Neurological Institute in Houston. “It increases synaptic density.”

With nearly 72 million Americans turning 65 over the next two decades, physicians need the tools to handle growing patient concerns about how to best maintain brain health. Armed with this new brand of science, frontline physicians will be better equipped to address the needs of aging baby boomers, already in the throes of the brain fitness revolution. “They are the gatekeepers of information, and people listen,” says Eduardo Locatelli, MD, MPH, a neurologist and medical director of the Florida Neuroscience Center in Fort Lauderdale. Dr. Locatelli implements brain fitness techniques for his postsurgery epilepsy patients as well as patients who present with mild- to moderate-stage Alzheimer’s and dementia. “Encourage new experiences. … Use it or lose it. Challenge it and gain.”

The plastic brain

Within the brain, the pathways and regions that are most utilized generally grow and become stronger while other parts shrink. “The brain is very Darwinian, it’s survival of the fittest,” says Edward Taub, PhD, a behavioral neuroscientist at the University of Alabama at Birmingham, who has researched neuroplasticity since the 1970s. “At one time it was believed we did not use 90% of our brain. That is false. The brain is a zero sum game. Every part of the brain is used. It has enormous plasticity.”

Thus, by challenging the brain and forcing the use of different pathways, brain maps can be altered. And such changes offer young and old — even brain-injured individuals — an opportunity to learn or re-learn things. “Vocabulary can increase into age 90,” says Gary J. Kennedy, MD, a professor in the Dept. of Psychiatry and Behavioral Sciences at Albert Einstein College of Medicine. He also directs the geriatric psychiatry division at Montefiore Medical Center in the Bronx, N.Y. “As people age they may be slower, but they are capable of more and more complex projects.”

Brain volume shrinks up to 1% every year after age 65.

To best illustrate neuroplasticity, consider stroke patients with damaged limbs. Contrary to traditional therapy, which works to strengthen the good limb, Taub restrains the uncompromised limb, forcing patients to use the damaged arm or leg. The therapy, constraint-induced movement therapy, also known as CI therapy, helps to rewire the brain.

“The more you use it, more neurons are available … the more demand for cortical space and the more the patient is able to use the [damaged] arm,” Taub said. Over time, small steps lead to improvements in activities of daily living. Ultimately, the damaged limb, at least in part, recovers because, although the brain does not regrow damaged areas, it re-routes around them.

When the brains of CI patients were examined, a tremendous increase in grey matter was detected, and interestingly, Taub says, the healthy part of the brain was recruited for the task. Some of Taub’s research was published in the Nov. 1, 2006, Journal of the American Medical Association.

CI applications are now being explored for other forms of brain injury.

Young brains, old brains?

Mental agility begins declining around age 24, says Dr. Fortanasce. But there is a big difference between agility and capacity. “I may be slower, but what I know now far outweighs what I knew at 24,” he says. “Some individuals perform their greatest creative work in late life. Verdi, for example, composed Othello at 73 and Falstaff at 79.”

Greg Jicha, MD, PhD, assistant professor of neurology at the University of Kentucky College of Medicine, shares related stories, such as that of an 82-year-old who learned to play the trumpet. “I’ve heard people say, ‘You can’t teach an old dog new tricks.’ That can’t be further from the truth,” says Dr. Jicha, who also heads the healthy brain aging research group at the university’s Sanders-Brown Center on Aging. “When you look at the plasticity of the adult brain, it is amazing.”

Mental agility, but not capacity, begins declining around age 24.

But age also brings anatomic changes. Brain weight and blood flow to the brain decrease by 20%. The number of fibers and nerves decrease by 37%. And brain volume shrinks up to 1% every year after age 65. Dr. Fortanasce also points to hormonal shifts, with the presence of dopamine and serotonin diminishing as cortisol, an aging hormone, increases. “Between age 20 and 70, we lose nearly 90% of youth hormones.”

So what keeps some brains younger than their chronology? Experts point to a prescription of neurobics. This concept includes life-long learning, trying new things, a healthy diet, social interactions, sleep and physical activity. “Exercise can actually increase neurogenesis and increase the size of the hippocampus,” says Dr. Fortanasce, who promotes isometrics and weight-bearing exercise. “Exercise also increases youth hormones. And novelty, doing new things, builds branches.”

In a 2006 study in the Journal of Aging and Physical Activity, Brandeis University researchers found that strength training increased the participants’ working memory span. The higher the level of resistance, the more memory improved, suggesting that strength training benefits not only the muscles but also the mind.

Dr. Locatelli suggests reversing daily patterns. People who take the same route to work every day need to push themselves beyond their comfort zones. A person can try to eat using his or her weaker hand, for instance. Or someone could listen to another type of music than the type usually favored. Activate unfamiliar areas of the brain, Dr. Locatelli says. The key is new places, socializing with different people, and reading new things.

And primary care physicians can help communicate this message.

“When a patient expresses concern about memory loss, never cast it off as associated with age,” says Tom Perls, MD, MPH, associate professor of medicine at Boston University Medical Center. Dr. Perls also heads the New England Centenarian Study. “This is an incredibly serious issue. Losing brain function is devastating.” Ask about memory. And rule out other conditions like depression or low thyroid first. “Encourage them to exercise the brain in novel and complex ways,” he says.

Exercising new connections

So what about dance steps? At McGill University in Montreal, researchers found that the tango may be better than walking for improving execution of complex tasks because it incorporates elements found in standard neurological rehabilitation programs. It’s also fun and social.

Participants, ages 62 to 90, were randomly assigned to a walking group or a tango dancing group, meeting two hours twice a week for 10 weeks. The tango group improved in balance, posture and motor coordination, as well as cognition.

Physical and mental exercise improve cognitive function.

According to new research published in the October issue of the journal Nature Neuroscience, University College London scientists say complex brain processes that enable the memorization and replication of activities such as playing the piano or riding a bicycle require the execution of complicated sequences of movements involving dozens of muscles. According to their research, pianists who learned and practiced their art from an early age had elevated amounts of myelin. This finding suggests that when people learn new skills, myelination might occur. Earlier studies indicated that brains of patients diagnosed with senile dementia had lowered amounts of myelin.

The emphasis, though, is the importance of embracing the complex and novel. And Joe Hardy, PhD, a cognition neuroscientist who develops brain plasticity training programs, says some common-sense advice from physicians is not based on good evidence. “They often recommend doing crossword puzzles,” he says. “But evidence suggests that crossword puzzles are not helpful.”

Hardy has been developing brain games for the San Francisco-based company Posit Science. The games — the Brain Fitness Program and Insight — have been tested in several randomized clinical trials funded by the National Institutes of Health. The results indicate that the brain age clock can roll back 10 years. “The key thing in terms of exercise for the brain: You need to do new things, thus forming new paths,” he says.

Some have even compared this new era in brain health to the 1950s, when heart health came to the fore. “New things are coming out all the time, and we are going to see a revolution in brain health,” Hardy says. “I think this is going to change the way people age.”


 

 ADDITIONAL INFORMATION: 

Increasing cognitive reserve

Who will live to be 100?

In a bit of fortune-telling fun, a series of lifestyle-related questions might offer a calculated prediction. The Life Expectancy Calculator can help patients find out how they rate right now and how changes in diet, exercise or sleep patterns might add years to the forecast. The calculator is available online (www.livingto100.com). This tool was created by Tom Perls, MD, MPH, associate professor of medicine at Boston University Medical Center, who heads the New England Centenarian Study.

A related and very important question is whether your patients’ brains — or maybe your own — will stay young as bodies age.

According to Dr. Perls, building cognitive reserve delays the onset of memory loss, and research suggests that novel and complex brain activities can delay cognitive decline and extend lifespan. “There’s a natural tendency to lose muscle as we age,” he says, and by building cognitive reserve, people are exercising their temporal lobes as they would their quads.

Dr. Perls has categorized a series of games based on cognitive function, available online (fun.eons.com/brain_games). For instance, stimulating areas in the temporal and frontal lobes with games that focus on recall and retention of past and present information targets memory. For language, focus on the parietal lobe with word-building games that prompt production and understanding of spoken and written communication. Exercising the frontal lobe can be done with problem-solving puzzles and strategy games in which players control and apply mental skills.

For motor function, engage the parietal lobe edge with navigation-type games that encourage body movement through the interaction of the brain, nerves and muscles. For visual-spatial skills, stimulate the occipital and temporal lobes. Games involving discrimination, perception, attention and tracking objects visually can achieve this goal.